One-week triple therapy with omeprazole, amoxycillin and tinidazole for Helicobacter pylori infection: The significance of imidazole resistance (2024)

Thijs, J. C., Van Zwet, A. A., Thijs, W. J., Van Der Wouden, E. J. (1997). One-week triple therapy with omeprazole, amoxycillin and tinidazole for Helicobacter pylori infection: The significance of imidazole resistance. Alimentary Pharmacology and Therapeutics, 11(2), 305-309. https://doi.org/10.1046/j.1365-2036.1997.155329000.x

Thijs, J. C. ; Van Zwet, A. A. ; Thijs, W. J. et al. / One-week triple therapy with omeprazole, amoxycillin and tinidazole for Helicobacter pylori infection : The significance of imidazole resistance. In: Alimentary Pharmacology and Therapeutics. 1997 ; Vol. 11, No. 2. pp. 305-309.

@article{2b92ad53ccba42d6bdc7985cd30c555b,

title = "One-week triple therapy with omeprazole, amoxycillin and tinidazole for Helicobacter pylori infection: The significance of imidazole resistance",

abstract = "Background: Triple therapy involving a proton pump inhibitor and two antibiotics has been suggested as an effective treatment for Helicobacter pylori infection. The impact of imidazole resistance on the efficacy of such regimens is largely unknown.Methods: One hundred patients with culture proven H. pylori infection were treated with omeprazole 40 mg b.d., amoxycillin 1000 mg b.d., and tinidazole 500 mg b.d., for one week. Pre-treatment imidazole susceptibility was measured by disk diffusion. Resistance was confirmed by E-test. Eradication was assessed by endoscopy 6-8 weeks after the end of treatment. In cases of doubt a 13C-urea breath test was performed. Side-effects were scored using a semiquantitative scale.Results: H. pylori was eradicated in 95% of the patients with an imidazole-susceptible strain and in 69% of the patients with a resistant strain (P < 0.005). Significant side-effects were seen in 12%.Conclusion: This proton pump inhibitor triple therapy is a simple, reasonably effective regimen with few significant side-effects. The efficacy is dependent on the susceptibility of the infecting H. pylori strain.",

author = "Thijs, {J. C.} and {Van Zwet}, {A. A.} and Thijs, {W. J.} and {Van Der Wouden}, {E. J.} and A. Kooy",

year = "1997",

doi = "10.1046/j.1365-2036.1997.155329000.x",

language = "English",

volume = "11",

pages = "305--309",

journal = "Alimentary Pharmacology and Therapeutics",

issn = "0269-2813",

publisher = "Wiley",

number = "2",

}

Thijs, JC, Van Zwet, AA, Thijs, WJ, Van Der Wouden, EJ 1997, 'One-week triple therapy with omeprazole, amoxycillin and tinidazole for Helicobacter pylori infection: The significance of imidazole resistance', Alimentary Pharmacology and Therapeutics, vol. 11, no. 2, pp. 305-309. https://doi.org/10.1046/j.1365-2036.1997.155329000.x

One-week triple therapy with omeprazole, amoxycillin and tinidazole for Helicobacter pylori infection: The significance of imidazole resistance. / Thijs, J. C.; Van Zwet, A. A.; Thijs, W. J. et al.
In: Alimentary Pharmacology and Therapeutics, Vol. 11, No. 2, 1997, p. 305-309.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - One-week triple therapy with omeprazole, amoxycillin and tinidazole for Helicobacter pylori infection

T2 - The significance of imidazole resistance

AU - Thijs, J. C.

AU - Van Zwet, A. A.

AU - Thijs, W. J.

AU - Van Der Wouden, E. J.

AU - Kooy, A.

PY - 1997

Y1 - 1997

N2 - Background: Triple therapy involving a proton pump inhibitor and two antibiotics has been suggested as an effective treatment for Helicobacter pylori infection. The impact of imidazole resistance on the efficacy of such regimens is largely unknown.Methods: One hundred patients with culture proven H. pylori infection were treated with omeprazole 40 mg b.d., amoxycillin 1000 mg b.d., and tinidazole 500 mg b.d., for one week. Pre-treatment imidazole susceptibility was measured by disk diffusion. Resistance was confirmed by E-test. Eradication was assessed by endoscopy 6-8 weeks after the end of treatment. In cases of doubt a 13C-urea breath test was performed. Side-effects were scored using a semiquantitative scale.Results: H. pylori was eradicated in 95% of the patients with an imidazole-susceptible strain and in 69% of the patients with a resistant strain (P < 0.005). Significant side-effects were seen in 12%.Conclusion: This proton pump inhibitor triple therapy is a simple, reasonably effective regimen with few significant side-effects. The efficacy is dependent on the susceptibility of the infecting H. pylori strain.

AB - Background: Triple therapy involving a proton pump inhibitor and two antibiotics has been suggested as an effective treatment for Helicobacter pylori infection. The impact of imidazole resistance on the efficacy of such regimens is largely unknown.Methods: One hundred patients with culture proven H. pylori infection were treated with omeprazole 40 mg b.d., amoxycillin 1000 mg b.d., and tinidazole 500 mg b.d., for one week. Pre-treatment imidazole susceptibility was measured by disk diffusion. Resistance was confirmed by E-test. Eradication was assessed by endoscopy 6-8 weeks after the end of treatment. In cases of doubt a 13C-urea breath test was performed. Side-effects were scored using a semiquantitative scale.Results: H. pylori was eradicated in 95% of the patients with an imidazole-susceptible strain and in 69% of the patients with a resistant strain (P < 0.005). Significant side-effects were seen in 12%.Conclusion: This proton pump inhibitor triple therapy is a simple, reasonably effective regimen with few significant side-effects. The efficacy is dependent on the susceptibility of the infecting H. pylori strain.

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U2 - 10.1046/j.1365-2036.1997.155329000.x

DO - 10.1046/j.1365-2036.1997.155329000.x

M3 - Article

C2 - 9146767

AN - SCOPUS:0030972411

SN - 0269-2813

VL - 11

SP - 305

EP - 309

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

IS - 2

ER -

Thijs JC, Van Zwet AA, Thijs WJ, Van Der Wouden EJ, Kooy A. One-week triple therapy with omeprazole, amoxycillin and tinidazole for Helicobacter pylori infection: The significance of imidazole resistance. Alimentary Pharmacology and Therapeutics. 1997;11(2):305-309. doi: 10.1046/j.1365-2036.1997.155329000.x